Characterization and Antimicrobial Studies of Synthesized Aluminum Acetylacetonate

Japhet, T.*, Ugye, J. T., Onen, A.I. and Abakpa A.M.
Page No.59-69

Aluminum acetylacetonate was synthesized in an aqueous ammonia solution through the reaction of acetylacetone with aluminum sulfate. Both the ligand and synthesized complex were characterized using infrared and UV-visible spectroscopy. The antimicrobial properties of the complexes were evaluated using the disc diffusion method, and the Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal/Fungicidal Concentration (MBC/MFC) were also determined. The results indicated that the complexes had a high yield of 81.46%, exhibited high melting points ranging from 185 to 207°C, and had low molar conductivity of 13.87 Ω-1cm2mol-1. The complex was soluble in acetone, ethanol, methanol, dimethyl sulfoxide (DMSO), and dimethylformamide (DMF), but insoluble in hexane and water. In the infrared spectrum, significant changes were observed in the complex compared to the ligand, particularly a shift in the C=O peak from 1584.1 to 1520.8 cm−1 after coordination. Acetylacetone exhibited maximum absorption at 329 nm, while the complex showed a shift to 343 nm in its electronic spectra. The complex exhibited strong antimicrobial activity against most microbes, with exceptions including Vancomycin resist enterococci, Klebsiella pneumonia, Helicobacter pylori and Proteus mirabilis. Aluminum acetylacetonate demonstrated superior antimicrobial activity against Methicillin resist Staph aureus, Campylobacter fetus and Pseudomonas aeruginosa when compared to the control drugs (Ciprofloxacin and Fluconazole), highlighting its potential as an effective antimicrobial agent.
Keywords: Characterization, Antimicrobial activity, Aluminum, Acetylacetone and Metal complex.