THE HISTORY OF RABIES IN TUNISIA AND THE DEVELOPMENT OF THE RABIES VACCINE

Maha Gasmi¹, Ziad Rahma²
Page No. 25-33

Over 55,000 people are killed by rabies each year, which continues to be a hazard to worldwide public health. Due to the number of years lost as a result of the disease, rabies is listed as the sixth most significant infectious disease. An illustrious history of more than 120 years has gone into the improvement of rabies vaccination for animals and humans. This review describes the different types of rabies virus vaccines and the development of replication-defective or monocyclic live rabies virus-based vectors for use as single-dose human rabies vaccinations using reverse genetics methods.  
Key words: Rabies virus, Vaccination, Vaccines, genetics methods.