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CYTOMEGALOVIRUS AND PREGNANCY: CONTRIBUTION OF VIROLOGY LABORATORY


T.Doblali [1], R.Roukhsi[2]
Page No. 223-229


Abstract

Cytomegalovirus infection is the most common viral infection reaching the fetus. The infection can
be transmitted in utero from maternal primary infection or during reactivation of infection in an
HIV-positive mother before pregnancy, which is a situation with high fetal and neonatal risk. The
frequency and severity of congenital infection are very different depending on the case and it is
therefore essential to make the differential diagnosis between primary infection and reactivation. In
this context, there is no gold standard test and the presence of IgM is still too often seen as a test for
recent infection. Various techniques have been developed to improve the diagnosis. Among these
new approaches, the most used is the measurement of IgGavidity which may exclude a recent
infection in many cases. Evidence of fetal infection is provided by the research CMV in amniotic
fluid culture and / or PCR; performance of these two techniques in terms of sensitivity and
specificity are comparable. However, please keep in mind that if the detection of virus in the
amniotic fluid sign congenital infection, it is not possible to assess the severity. Despite this
multitude of test there is no legislation in Morocco as well as in developed countries in a systematic
search for CMV during pregnancy status.
Key words: Cytomegalovirus; Congenital infection; greed; PCR; legislative.


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